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style='border-collapse:collapse;mso-yfti-tbllook:1184'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> <td style='padding:.75pt .75pt .75pt .75pt'> <p align=center style='text-align:center'><strong><span style='font-size: 13.5pt;font-family:"Calibri","sans-serif"'>How to Achieve Peak Performance of Your Lyophilization Process</span></strong><span style='font-size:13.5pt; font-family:"Calibri","sans-serif"'><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:1'> <td style='padding:.75pt .75pt .75pt .75pt'> <p align=center style='text-align:center'><span style='font-size:10.5pt; font-family:"Calibri","sans-serif"'>" &nbsp;&nbsp;Reduce Cycle Length<o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:2'> <td style='padding:.75pt .75pt .75pt .75pt'> <p align=center style='text-align:center'><span style='font-size:10.5pt; font-family:"Calibri","sans-serif"'>" &nbsp;&nbsp;Improve Product Quality and Yield<o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:3'> <td style='padding:.75pt .75pt .75pt .75pt'> <div class=MsoNormal align=center style='text-align:center'><span style='mso-fareast-font-family:"Times New Roman"'> <hr size=2 width="100%" align=center> </span></div> </td> </tr> <tr style='mso-yfti-irow:4;mso-yfti-lastrow:yes'> <td style='padding:.75pt .75pt .75pt .75pt'> <p align=center style='text-align:center'><span style='font-size:7.5pt; font-family:"Calibri","sans-serif"'><a href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=5c52ad39-784d-7d42-babb-4ca5e0c1c327&amp;identifier=e20bf3af-cda8-d1c7-a034-4cb317160099" target="_newwin">Forward To A Friend</a><o:p></o:p></span></p> </td> </tr> </table> </div> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"; display:none;mso-hide:all'><o:p>&nbsp;</o:p></span></p> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 style='border-collapse:collapse;mso-yfti-tbllook:1184'> <tr style='mso-yfti-irow:0;mso-yfti-firstrow:yes'> <td colspan=2 style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 id="_x0000_i1026" src="http://bioc.us/wpress/wp-content/uploads/2010/10/headerT.png" style='border-bottom-width:0px;border-left-width:0px;border-right-width:0px; border-top-width:0px;height:48px;margin-bottom:0px;margin-left:0px; margin-right:0px;margin-top:0px;vertical-align:middle;width:566px' alt=Header align=center><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:1'> <td colspan=2 style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 id="_x0000_i1027" src="http://bioc.us/wpress/wp-content/uploads/2010/09/menuT.png" style='width:566px' alt=Menu align=center><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:2'> <td colspan=2 style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 id="_x0000_i1028" src="http://bioc.us/wpress/wp-content/uploads/2010/10/LineT.jpg" style='height:4px;width:566px' alt=LineT1 align=center><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:3'> <td colspan=2 style='padding:.75pt .75pt .75pt .75pt'> <p align=center style='text-align:center'><span style='font-size:11.5pt; font-family:"Calibri","sans-serif"'> <a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=d8558736-24bb-7653-4ada-4ca5dd355cbe&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='color:#632523;text-decoration:none;text-underline:none'>About BioC</span></a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <a style="text-decoration:none;" 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style='color:#632523;text-decoration:none;text-underline:none'> www.bioc.us</span></a>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=93af0fbf-3b60-1173-a3ac-4ca5dd278f7f&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='color:#632523;text-decoration:none;text-underline:none'>Contact Us</span></a><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:4'> <td colspan=2 style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 id="_x0000_i1029" src="http://bioc.us/wpress/wp-content/uploads/2010/10/LineT.jpg" style='height:4px;width:566px' alt=LineT1 align=center><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:5'> <td colspan=2 style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 id="_x0000_i1030" src="http://bioc.us/wpress/wp-content/uploads/2010/10/LineWht.jpg" style='height:4px;width:566px' alt=Spacer1 align=center><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:6'> <td width=303 valign=top style='width:227.25pt;padding:.75pt 7.5pt .75pt 7.5pt'> <p><strong><span style='font-size:13.5pt;font-family:"Calibri","sans-serif"'>Top 5 List</span></strong><span style='font-size:13.5pt;font-family:"Calibri","sans-serif"'><br> </span><span style='font-size:10.5pt;font-family:"Calibri","sans-serif"'>Lyophilization creates stable, safe pharmaceutical products for solution formulations that lack stability over a normal shelf-life. However, it is an expensive process in terms of time, equipment and operating costs. To ensure your lyophilized product is characterized and lyophilization cycle is optimized, ask yourself these questions:</span><span style='font-size:13.5pt;font-family:"Calibri","sans-serif"'><o:p></o:p></span></p> <ol start=1 type=1> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level1 lfo1;tab-stops:list .5in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>Has thermal analysis by differential scanning calorimetry (DSC) and freeze dry microscopy (FDM) been performed to develop and characterize the cycle?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level1 lfo1;tab-stops:list .5in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>Is your drug product crystalline or amorphous? <o:p></o:p></span></li> <ul type=disc> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>Does it exhibit eutectic melt?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>Does it have a critical glass transition temperature?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>What is its collapse temperature?<o:p></o:p></span></li> </ul> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level1 lfo1;tab-stops:list .5in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>Do you have a comprehensive development history supporting your critical lyophilization parameters?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level1 lfo1;tab-stops:list .5in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>Does the product exhibit shrinkage, collapse, breakage, stability or reconstitution issues?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level1 lfo1;tab-stops:list .5in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>Have the following been determined and documented? <o:p></o:p></span></li> <ul type=disc> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>For cooling, what criteria determined the setting cooling temperature and rate?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>For freezing, what criteria determined the holding time?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>For annealing, what requirements caused the need for this step?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>For primary drying, is product temperature close to, but not exceeding the critical temperature?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>For primary drying of multiple presentations, how do temperature, pressure, solute density, fill depth and container type and dimensions correlate?<o:p></o:p></span></li> <li class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt: auto;mso-list:l0 level2 lfo1;tab-stops:list 1.0in'><span style='font-size:10.5pt;font-family:"Calibri","sans-serif";mso-fareast-font-family: "Times New Roman"'>For secondary drying, what percent moisture is required for product stability?<o:p></o:p></span></li> </ul> </ol> </td> <td width=220 valign=top style='width:165.0pt;border:double #632523 2.25pt; background:#632523;padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><o:p>&nbsp;</o:p></span></p> <p align=center style='text-align:center'><strong> <span style="font-size:16.5pt;font-family:Calibri;color:white;text-decoration:underline;">Thermal Analysis</span></strong><span style='font-size:16.5pt;font-family:"Calibri","sans-serif";color:white'><br> </span><span style='font-size:10.5pt;font-family:"Calibri","sans-serif"; color:white'>Download these case studies:</span><span style='font-size:16.5pt; font-family:"Calibri","sans-serif";color:white'><br> <br> <a style="text-decoration:underline;color:#ffffff;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=a804f3eb-0e59-cce2-cdae-4ca3e946a3b4&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='color:white'>Case Study 1</span> </a><br> <a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=a804f3eb-0e59-cce2-cdae-4ca3e946a3b4&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='font-size:13.5pt;color:white;text-decoration:none;text-underline:none'> During the preclinical phase</span> </a><br> <br> <a style="text-decoration:underline;color:#ffffff;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=339cf722-d52d-04b8-6e53-4ca3e91a41fb&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='color:white'>Case Study 2</span> </a><br> <a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=339cf722-d52d-04b8-6e53-4ca3e91a41fb&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='font-size:13.5pt;color:white;text-decoration:none;text-underline:none'> During the clinical phase</span></a><br> <br> <a style="text-decoration:underline;color:#ffffff;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=d48e025f-d6f1-67f5-0f3b-4ca3e9b1b169&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='color:white'>Case Study 3</span> </a><br> <a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=d48e025f-d6f1-67f5-0f3b-4ca3e9b1b169&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='font-size:13.5pt;color:white;text-decoration:none;text-underline:none'> During the commercial phase</span> </a><br> <br> <a style="text-decoration:underline;color:#ffffff;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=d92fd9c2-3e32-c82c-6012-4ca3ea7f9f29&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='color:white'>Top 5 Checklist</span></a><br> <a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=d92fd9c2-3e32-c82c-6012-4ca3ea7f9f29&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='font-size:13.5pt;color:white;text-decoration:none;text-underline:none'> For lyophilization</span> </a><br> <br> <a style="text-decoration:underline;color:#ffffff;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=d4d433cc-b7fc-a525-5993-4ca3eaff4d5c&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='color:white'>For More Information<br> </span></a><a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=d4d433cc-b7fc-a525-5993-4ca3eaff4d5c&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='font-size:13.5pt;color:white;text-decoration:none;text-underline:none'> Click Here</span></a><o:p></o:p></span></p> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><o:p>&nbsp;</o:p></span></p> <div class=MsoNormal align=center style='text-align:center'><span style='mso-fareast-font-family:"Times New Roman"'> <hr size=2 width="100%" align=center> </span></div> <p class=MsoNormal style='margin-bottom:12.0pt'><span style='mso-fareast-font-family: "Times New Roman"'><o:p>&nbsp;</o:p></span></p> <p align=center style='text-align:center'> <strong><span style="font-size:16.5pt;font-family:Calibri;color:white;text-decoration:underline;">Coming Up:</span></u></strong><span style='font-size:16.5pt;font-family:"Calibri","sans-serif";color:white'><o:p></o:p></span></p> <p align=center style='text-align:center'><span style='font-size:16.5pt; font-family:"Calibri","sans-serif";color:white'> <a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=2a9baf10-e2ae-9d2e-7b95-4cab2c364876&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='color:white;text-decoration:none;'>Meet us at AAPS</span></a><br> <a style="text-decoration:none;" href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=2a9baf10-e2ae-9d2e-7b95-4cab2c364876&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6"> <span style='font-size:13.5pt;color:white;text-decoration:none;text-underline:none'>Nov. 14-18<br> New Orleans, LA<br> Booth #2855</span></a><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:7'> <td width=303 style='width:227.25pt;padding:.75pt .75pt .75pt 7.5pt'> <p><span style='font-size:10.5pt;font-family:"Calibri","sans-serif"'>If you do not have the answers to these questions, download our <a href="https://bioc.sugarondemand.com/index.php?entryPoint=campaign_trackerv2&amp;track=d92fd9c2-3e32-c82c-6012-4ca3ea7f9f29&amp;identifier=82b79035-bcf5-55a2-4365-4cb316090eb6">Top 5 Checklist </a>for tools and sources.<o:p></o:p></span></p> </td> <td style='padding:.75pt .75pt .75pt .75pt'></td> </tr> <tr style='mso-yfti-irow:8'> <td colspan=2 style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 id="_x0000_i1032" src="http://bioc.us/wpress/wp-content/uploads/2010/10/LineWht.jpg" style='height:4px;width:566px' alt=Spacer2 align=center><o:p></o:p></span></p> </td> </tr> <tr style='mso-yfti-irow:9;mso-yfti-lastrow:yes'> <td colspan=2 style='padding:.75pt .75pt .75pt .75pt'> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"'><img border=0 id="_x0000_i1033" src="http://bioc.us/wpress/wp-content/uploads/2010/10/LineT.jpg" style='height:4px;width:566px' alt=LineT2 align=center><o:p></o:p></span></p> </td> </tr> </table> </div> <p class=MsoNormal><span style='mso-fareast-font-family:"Times New Roman"; display:none;mso-hide:all'><o:p>&nbsp;</o:p></span></p> <div align=center> <table class=MsoNormalTable border=0 cellspacing=0 cellpadding=0 width=566 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